Flow diagram and example of how a combined TCE-expression algorithm can be used to identify an optimal HLA-11/12 donor (HLA-A, -B, -C, -DRB1, and -DQB1-matched 10/10 + HLA-DPB1 single mismatch) in data set 3. This data set involves 2545 HLA-11/12 expression-applicable patients who underwent transplantation filtered from 5032 HLA-10/10 (50.6%) patients who underwent transplantation. (A) Expression (Ex)-prioritized and TCE-prioritized routes for categorizing HLA-DPB1 match types between the recipient and donor. (B) An example search showing different final candidate HLA-11/12 search lists between expression-prioritized or TCE-prioritized applications. The example of search typing includes multiple allele codes that encode several possible alleles. Match category shorthand includes Ex– (expression-unfavorable), Ex+ (expression-favorable), TCE+ (TCE-permissive), and TCE– (TCE-nonpermissive). The golden boxes outline the final candidate donors after applying and filtering models. The grayed out boxes indicate that the donor did not pass the filtering step of the first model.