PRS analysis for eGFR using summary statistics from the COGENT-Kidney Consortium eGFR GWAS. (A) Forest plot depicting the FE eGFR meta-analysis of OMG-SCD and Walk-PHaSST generated using metafor at the maximizing P value threshold (P_T) = .579. (B) Bar plot depicting model fit (R²) of the COGENT-Kidney Consortium eGFR PRS predicting eGFR in OMG-SCD at a wide range of P value thresholds. (C) Bar plot depicting model fit (R²) of the COGENT-Kidney Consortium eGFR PRS predicting eGFR in Walk-PHaSST at a wide range of P value thresholds. FE, fixed effects.