TP53 median variant allele frequencies (MAFs) and mutation specifics among PTCL cases with a TP53 mutation (n = 21). (A) MAF of TP53 mutations as compared with all other gene mutations in each tumor sample (n = 21). Each of these 21 patients’ biopsies are represented on the x-axis. Red symbols represent the MAF of the TP53 mutation. Black symbols represent the MAF of any non-TP53–mutated gene found in the same biopsy. The solid lines represent the median MAF of all mutations occurring in the biopsy sample. (B) Lollipop plot of TP53 mutations (n = 21). Each colored symbol represents a specific TP53 mutation along the entire coding region. The green boxed region represents the transactivation domain (P53_TAD). The red boxed region represents the DNA binding domain (P53). The blue boxed region represents the tetramerization domain (P53_tetramer). The next 2 rows signify that all mutations are listed in the OncoKB database as likely oncogenic, and 15 have been reported as cancer hotspot mutations. The bottom row illustrates the exon structure of the TP53 gene.