Schema of the 3 cohorts. ASC samples were collected from patients in cohort 1. Pre-ASCT ASC samples and post-ASCT surveillance plasma and PBMC samples were collected from patients in cohort 2. In addition, a subset of cohort 2 patients had 1 pre-ASCT PB sample collected. Patients in cohort 3 had post-ASCT surveillance plasma and PBMC samples collected, and a subset of patients had available pre-ASCT ASC samples. The samples are color-coded by cohort (cohort 1, purple; cohort 2, green; cohort 3, red).