Association of metabolites with severity of CRS. (A) Heatmap of median relative abundance of 72 metabolites (rows) significantly associated with CRS severity (P < .05, q < .10), stratified by maximum observed grade of CRS (columns). Color indicates the log₂-transformed median relative abundance of each group and metabolites are ordered by their relative abundance in CRS grades 2 to 4. (B) Relative abundance of the most statistically significant metabolites that were negatively associated with maximum observed CRS grade. The ordinal logistic regression q value is displayed in the graph title and the q values from pairwise t test comparisons are displayed on the graph.