Association of metabolites with time-to-CRS onset. (A) Forest plot of HRs and 95% CIs for the 155 metabolites, measured on the day of apheresis, associated with time-to-CRS onset from day of treatment initiation (P < .05, q < .10). (B) Kaplan-Meier curves for the 9 metabolites with the highest or lowest HRs display the fraction of patients who experienced CRS, stratified by median metabolite abundance. The dotted red and blue lines indicate the median time-to-CRS for each group.