Figure 3.
NFIX colocalizes with multiple hematopoietic transcription factors. (A) Signal plot showing enrichment of NFIX peaks in Nfix+/+ HPC5 cells as compared with NFIX signals in Nfix−/− HPC5 cells. (B) Genomic annotation pie chart showing the distribution of NFIX peaks. (C) Top left, signal plot showing enrichment of H3K27ac peaks centered around NFIX peaks in Nfix+/+ HPC5 cells. Top right, schematic detailing focus on enhancer regions, where NFIX (red track) and H3K27ac (blue track) signals overlap. Below, HOMER motif discovery analysis identifies the primary motif as NFIX, as well as multiple secondary motifs. (D) Representative tracks showing the overlap of NFIX (red track) in Nfix+/+ HPC5 cells and additional hematopoietic factors (pink tracks) in HPC7 cells at the Il10ra gene locus. (E) Signal plots showing the enrichment of hematopoietic factors, PU.1, STAT3, RUNX1, and NFE2 (data from HPC7 cells), centered around NFIX peaks (data from HPC5 cells).

NFIX colocalizes with multiple hematopoietic transcription factors. (A) Signal plot showing enrichment of NFIX peaks in Nfix+/+ HPC5 cells as compared with NFIX signals in Nfix−/− HPC5 cells. (B) Genomic annotation pie chart showing the distribution of NFIX peaks. (C) Top left, signal plot showing enrichment of H3K27ac peaks centered around NFIX peaks in Nfix+/+ HPC5 cells. Top right, schematic detailing focus on enhancer regions, where NFIX (red track) and H3K27ac (blue track) signals overlap. Below, HOMER motif discovery analysis identifies the primary motif as NFIX, as well as multiple secondary motifs. (D) Representative tracks showing the overlap of NFIX (red track) in Nfix+/+ HPC5 cells and additional hematopoietic factors (pink tracks) in HPC7 cells at the Il10ra gene locus. (E) Signal plots showing the enrichment of hematopoietic factors, PU.1, STAT3, RUNX1, and NFE2 (data from HPC7 cells), centered around NFIX peaks (data from HPC5 cells).

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