Figure 3.
SR604 normalizes the tail-bleeding time of humanized hemophilic mice. Tail-bleeding time was quantified as microliters of blood loss (hemoglobin content) per gram of mouse in 20 minutes after mouse tail transection. PROC+/+;F8−/− (A) and PROC+/+;F9−/−mice (B) were treated with PBS or SR604 antibody by subcutaneous injection at the indicated doses. After 24 hours, tail bleeding was measured for 20 minutes. As positive controls, a group of PROC+/+;F8−/− mice were injected with FVIII factor (1 IU per mouse) IV into the orbit for 15 minutes before the tail cutting, and a group of PROC+/+;F9−/−mice were injected with PCC (1 IU per mouse). Error bars represent standard error of the mean (n = 6 mice per group). ∗P < .05; ∗∗∗P < .001. PBS, phosphate-buffered saline.

SR604 normalizes the tail-bleeding time of humanized hemophilic mice. Tail-bleeding time was quantified as microliters of blood loss (hemoglobin content) per gram of mouse in 20 minutes after mouse tail transection. PROC+/+;F8−/− (A) and PROC+/+;F9−/−mice (B) were treated with PBS or SR604 antibody by subcutaneous injection at the indicated doses. After 24 hours, tail bleeding was measured for 20 minutes. As positive controls, a group of PROC+/+;F8−/− mice were injected with FVIII factor (1 IU per mouse) IV into the orbit for 15 minutes before the tail cutting, and a group of PROC+/+;F9−/−mice were injected with PCC (1 IU per mouse). Error bars represent standard error of the mean (n = 6 mice per group). ∗P < .05; ∗∗∗P < .001. PBS, phosphate-buffered saline.

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