Mean SAA-time profiles and corresponding mean plasma L-asparagine levels in the first treatment course by cohort and dosing schedule. The lower limit of quantitation (LLOQ) values were as follows: SAA = 0.0350 IU/mL; L-asparagine = 0.0250 μg/mL. Values below the LLOQ were graphed as 0 on the linear scale or omitted from the semilogarithmic scale. Only SAA is graphed on a semilogarithmic scale. ^aFor cohort 1a, the sample size for mean SAA levels and plasma asparagine levels ranged from 8 to 12 patients for all time points. For cohort 1b, the sample size ranged from 15 to 22 patients for all time points. For cohort 1c, the sample size ranged from 17 to 19 patients for all time points. ^bFor cohort 1a, the sample size for mean SAA levels and plasma asparagine levels was 7 patients for all time points. For cohort 1b, the sample size ranged from 27 to 32 patients for all time points. For cohort 1c, the sample size ranged from 18 to 23 for all time points. ^cFor cohort 1a, the sample size for mean SAA levels and plasma asparagine levels ranged from 6 to 8 patients for all time points. For cohort 1b, the sample size ranged from 23 to 29 patients for all time points. For cohort 1c, the sample size ranged from 6 to 8 patients for all time points.