IA lymphoid neoplasms after ALL. (A) Coronal (left) and axial (right) chest CT scans of a 4-year-old boy with persistent fever and cough during ALL maintenance therapy, demonstrating multiple nodular pulmonary lesions, subsequently diagnosed with EBV-positive DBCL. (B) Percentage of patients with involvement of different extranodal sites (data available for 60 patients). (C) A swimmer’s plot summarizing treatment and outcome of 10 patients for whom maintenance therapy had been reinitiated after achieving remission from lymphoid neoplasm. Patient numbers, lymphoid neoplasm subtype, and stage are depicted on the left. CT, computed tomography; CTL, cytotoxic T lymphocytes; LYG, lymphomatoid granulomatosis; MCU, mucocutaneous ulcer; MTX, methotrexate; 6MP, mercaptopurine.