Comparison of PRE, AUTO, and POST VAFs in 2 patients with MM-associated MDS/AML. Graphical representation of VAFs between PRE:AUTO, AUTO:POST, and PRE:POST samples for SHM5 (variant enrichment) and SHM6 (no enrichment). The clinical timing of PRE is indicated in “MM biopsy” of Figure 1. Black dashed circle indicates variant enrichment. Blue dashed circle indicates variant reduction. Each dot indicates a single variant. In the panels labeled CHIP, blue points (ie, true) indicate CHIP gene variants. GOI, genes of interest (ie, CHIP genes).