cfDNA BRAF V600E load in peripheral blood during the therapy. The figure represents the changes in cfDNA BRAF V600E allelic load in peripheral blood during various timepoints on protocol therapy and during the follow-up. The Y-axis is logarithmic, and each line represents a single patient allelic load trend, labeled by the respective IDs. The lowest limit of detection is represented by 0.05%, however, they were detected individually, based on the DNA concentration. Certain fluctuations can be observed after vemurafenib therapy cessation and during the follow-up period.