American Society of Hematology

Figure 1.

$A transcriptional map of primitive cells from the first trimester FL. (A) Schematic presentation of the data in the figure. (B) UMAP of cellular states within LIN–CD45+CD34+ FL cells at CS22 (2 donors) (C) Bead plot of DEGs between clusters, where the size of the circle is the fraction of cells with expression and the color represents the z-scored mean expression. (D) Cells from the different cell states in (B) were pseudobulked, and PCA was performed using the top 500 variably expressed genes. PC1 vs PC2 (left) and PC2 vs PC3 (right).$

A transcriptional map of primitive cells from the first trimester FL. (A) Schematic presentation of the data in the figure. (B) UMAP of cellular states within LIN^–CD45⁺CD34⁺ FL cells at CS22 (2 donors) (C) Bead plot of DEGs between clusters, where the size of the circle is the fraction of cells with expression and the color represents the z-scored mean expression. (D) Cells from the different cell states in (B) were pseudobulked, and PCA was performed using the top 500 variably expressed genes. PC1 vs PC2 (left) and PC2 vs PC3 (right).

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