Late infections from days 101 to 325 after BCMA–directed CAR T-cell therapy. The figure presents late infectious events from days 101 to 365 (n = 22) by pathogen type and individual infection. Between days 101 and 365 after cell infusion, 15 patients (15%) experienced 22 infectious events. Viral infections were the most frequent infectious event after day 100 (41%) and bacterial infections were less common after day 100 (27%). A total of 32% of infections were clinical pneumonia that was not delineated as bacterial or viral. There were no fungal infections identified after day 100. The case of disseminated varicella-zoster virus developed in a patient admitted to an outside facility with a vertebral fracture who was briefly off prophylaxis in that setting, and there was no evidence of acyclovir resistance and he improved on IV acyclovir. Overall, 17 of 22 (77%) of late infectious events were composed of respiratory infections involving the lungs, upper respiratory tract, or sinuses. Pneumonia NOS represents pneumonia diagnosed via clinical and radiographic criteria that could not be delineated as bacterial or viral. Amongst late infections, 7/7 cases of pneumonia were "Pneumonia NOS".