HRQoL at baseline and during the course of the treatment. Mean scores and 95% confidence intervals (vertical lines) of all the HRQoL subscales are given at baseline (T0), after 12 induction cycles (T1), 15 months after randomization (T2) and 12 months after completion of protocol treatment (T3). For functional subscales, a higher score represents a better HRQoL, for symptom subscales a higher score represents more symptoms. The dotted horizontal lines represent the calculated threshold for MID (Table 2). The P value represents the significance level of the change in HRQoL over time (supplemental Methods).