Contrast-enhanced ultrasound molecular imaging in Adamts13^−/− and Adamts13^−/−LDLR^−/− mice.Adamts13^−/−LDLR^−/−mice (aged 23-25 weeks) were put on high fat diet for 2 weeks before imaging, with microbubbles functionalized to detect platelet (A) and VWF (B) signals on the myocardial microcirculation. A challenge with LDL (300 μg/g body weight; IP) was administered 2 hours before imaging in Adamts13^−/− mice (aged 17-19 weeks). A challenge with VWF (5 μg/g body weight; IV) was administered 1 hour before imaging. P values were by t test.