Significantly mutated genes in BL. (A) Cumulative representation of recurrent copy number aberrations across BL and DLBCL identified by Genomic Identification of Significant Targets in Cancer, version 2.0 (GISTIC2.0) (default Q value threshold). (B) EBV-positive (N = 118) and EBV-negative (N = 112) BL tumors are shown separately, and each set of genes associated with a specific pathway is separately ordered to highlight mutual exclusivity. Mutations are colored on the basis of their predicted consequence, and the frequency of each variant type is tallied in the bar plots on the right. Focal gains and deletions were defined as those <1 Mbp. Mutation prevalence in EBV-positive (N = 118) and EBV-negative (N = 112) cases was subject to a Fisher exact test with Bonferroni correction and is shown in the bar plots on the left. ∗Q < 0.1, ∗∗Q < 0.05, and ∗∗∗Q < 0.01.