Identification of distinct genomic subgroups in BL and DLBCL. (A) Clustering solution from non–negative matrix factorization (NMF) utilizing a combination of simple somatic mutations, CNVs, SVs, SHM patterns, and hotspot mutations as features. The proportional abundance of each feature in the clusters is shown on the left side. Each individual feature is labeled on the right side of the heat map. IGH/K/L-MYC breakpoints were considered as separate features (labeled as “MYC_IG”), and when MYC was not translocated to IGH, IGK, or IGL, it was considered separately and labeled “MYC_not_IG.” The right annotation track depicts whether the feature significantly enriched in BL, DLBCL, or neither of these entities. Alluvial plots showing distribution of different entities by EBV status (B), age (C), or sex (D) between identified clusters. For all panels except A, only patient samples with available sex information are shown. IGH, immunoglobulin heavy chain; IGK, immunoglobulin light chain kappa; IGL, immunoglobulin light chain lambda.