Model of IL-1–mediated inflammaging as a driver of Tet2^+/−clonal hematopoiesis. Working model on positive feedback loop driving development of aberrant Tet2^+/− hematopoiesis induced by inflammaging-derived IL-1. Increased IL-1 levels derived from aged Tet2^+/− mature myeloid cells act directly on HSPCs favoring Tet2^+/− HSPC expansion (circular arrows), repopulation capacity, and multilineage differentiation (linear arrows) over WT HSPCs. IL-1–mediated Tet2^+/− clonal expansion can be modulated by the administration of IL-1R1 antagonist (anakinra). See Discussion for detailed explanation.