In a population-level analysis, Cheloor Kovilakam et al found that nonsynonymous germ line DDX41 variants were present in 1 in 129 individuals and DDX41-GPV were present in 1 out of 430 adults in the UK Biobank. In addition, the DDX41-GPV variant type influenced the risk of MDS/AML, with truncating and start-loss alterations conferring the highest risk. Professional illustration by Somersault18:24.