MYD88^L265P and CD79B^Y196F coexpression augments proximal BCR signaling in DLBCL. For each cell line: (Top) Immunoblot of pSYK, SYK, pBTK, and BTK in engineered DHL4, LY1, and LY7 cells at baseline and 2, 5, 10, 20, 40, 60, and 120 minutes after BCR crosslinking. (Bottom) Densitometry analysis of protein bands. Actin was used as a loading control. Data are representative of 1 of 3 independent experiments.