MYD88^L265Pexpression increases endolysosomal colocalization of MYD88 and DOCK8. (A) (Top) Confocal images of MYD88:LAMP1 PLA signals in DHL4, LY1, and LY7 parental (p), MYD88^WT (W)-, or MYD88^L265P (M)-overexpressing cells. (Bottom) Quantification data of n > 50 cells classified per condition. Violin plots, ∗∗∗P < .001; ∗∗∗∗P < .0001. (B) (Top) Confocal images of LAMP1:DOCK8 PLA signals in DHL4, LY1, and LY7 p, W-, or M-overexpressing cells. (Bottom) Quantification data of n > 70 cells classified per condition. Violin plots, ∗∗∗∗P < .0001. Asterisks represent P values in a Mann-Whitney test.