Spectrum of CH in age-related CH compared with the germ line RUNX1 carriers-without HM cohort. (A) Prevalence of CH in the control population compared with the germ line RUNX1 carriers-without HM cohort. The control population includes cohorts from Jaiswal et al³² and Genovese et al³³ (n = 27 783). The 0 to 18 age group is only available for the RUNX1 cohort. (B) Mutational spectrum of CH in the control population compared with the germ line RUNX1 carriers-without HM cohort. Graph shows the frequency of variants in individuals with CH in each cohort. The control population includes cohorts from Desai et al,³⁶ Abelson et al,³⁵ and Jaiswal et al.³² ∗P < .05, ∗∗P < .001, 2-proportions Z test, approximate to normal distribution, ±95% confidence interval.