Transcriptional mechanisms of gene activation in regenerative erythropoiesis. (A) Ssx2ip activities are involved in regulating centrosome stability.³⁵ In acute anemia, chromatin accessibility increased at an intronic GATA and TAL1-occupied E-box–GATA element in the Ssx2ip locus. Our model predicts that this element facilitates Ssx2ip upregulation in anemia. Ssx2ip knockdown in erythroid precursors isolated from anemic spleen revealed a role for Ssx2ip in colony formation and cell cycle regulation. (B) Expression levels of genes associated with S14E-like cis elements are inversely correlated with hematocrit levels in PHZ-induced models of acute anemia. Orange line, hematocrit levels; blue line, relative Ssx2ip expression.