CAR-ADR T cells effectively eliminate both activated T cells and tumor cells. (A) Schematic of a CAR-ADR T cell (left) and a representative flow plot showing expression of both receptors on primary human T cells (right). (B) Effector T cells and autologous activated T cell targets were cocultured at a 1:2 ratio. Residual target counts (normalized to target-only condition) at 24 hours post coculture are shown. (C) Effector T cells and NALM6 tumor targets were cocultured at a 1:2 ratio. Residual target counts (normalized to target-only condition) at 24 hours post coculture are shown. (D) Effector T cells, autologous activated T cells, and NALM6 were cocultured at a 1:1:1 ratio. Residual target counts (normalized to target-only condition) at 24 hours post coculture are shown. In panels B-D, mean ± SD values are shown. Each dot represents data from an individual donor. P values were calculated using 1-way ANOVA followed with Tukey correction.