American Society of Hematology

Figure 7.

Effect of TTI-101 on pY-peptide binding in vitro and on STAT3-dependent growth in vivo of WT or STAT3 SH2D GOF mutants. (A) IC50 of TTI-101 inhibition of binding of STAT3 WT or GOF mutant protein to pY1086-peptide measured by SPR. (B-C) Representative IC50 curves of 2 experiments each showing TTI-101 inhibition of growth of STAT3−/− MEF cells stably transfected with WT (left) or the STAT SH2D GOF mutant, D661Y (right) and grown in medium with 0.5% FBS (B) or in media with 0% serum (C).

Effect of TTI-101 on pY-peptide binding in vitro and on STAT3-dependent growth in vivo of WT or STAT3 SH2D GOF mutants. (A) IC₅₀ of TTI-101 inhibition of binding of STAT3 WT or GOF mutant protein to pY1086-peptide measured by SPR. (B-C) Representative IC₅₀ curves of 2 experiments each showing TTI-101 inhibition of growth of STAT3^−/− MEF cells stably transfected with WT (left) or the STAT SH2D GOF mutant, D661Y (right) and grown in medium with 0.5% FBS (B) or in media with 0% serum (C).

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