FFS of patients with PNH bearing a rare CFH variant (red) vs without a CFH variant (blue). The 6-year FFS for the no-CFH group was 39.3 months (95% CI, 28.1-50.3). Events included, first red blood cell transfusion after the eculizumab loading dose, thrombosis, eculizumab dose increase to 1200 mg, or occurrence of death.