Outcome of subgroups of patients with double-hit disease, defined by unifying lesions. Kaplan-Meier plots for PFS for double-hit subgroups defined by presence of del(1p) (A), del(17p) (B), gain(1q) (C), t(4;14) (D), and t(14;16)/t(14;20) (E); P values: Wald-P.