HR and NHR t(4;14) based on landmark survival analysis. (A) Density plot of patient overall OS in t(4;14) NDMM patients. (B) Association of genomic and risk features in t(4;14) NDMM patients. Blue indicates significant positive association; red indicates significant negative association. Size and color intensity scaled to −log(fdr_p). FDR P values >.05 are set to gray. (C) Translocation breakpoint of HR and NHR patients relative to the start of NSD2. Zero on the x-axis indicates the position of NSD2 gene, with positive numbers representing breakpoints occurring within the NSD2 gene. Negative numbers indicate locations upstream of NSD2.