TF concentration dependent effect of GPVI-induced platelet activation in TG. Parallel samples of WB (A) and PRP (B) were triggered in the absence of TF (i), or with 0.1 pM TF (ii), 1 pM TF (iii), or 10 pM TF (iv). Preincubation was with 25 μg/mL CRP-XL, where indicated (+CRP). Traces are representative of 3 independent experiments (A and B). Plots of TG lagtime and thrombin peak levels in the whole blood (C-D) or PRP (E-F). Means ± SD (n = 3); 2-way ANOVA, ∗P < .05; ∗∗P < .01; ∗∗∗P < .001; ∗∗∗∗P < .0001. See further details in Datafile 1.