Biologic risk factors in HGBL-NOS. PFS based on (A) the cell of origin via immunohistochemistry, (B) DEL phenotype (MYC and BCL2 expression via immunohistochemistry), (C) presence of MYC alterations via FISH, and (D) presence of TP53 alterations (by sequencing or p53 IHC); (E-H) analogous curves for OS; P values were obtained using log-rank test (log-rank test for trend as indicated).