Distribution of CRS grade by dosing visit for Parts C and D. (A-B) Incidence and grade of CRS were observed to be highest on the first dose and on weekly step-up dosing. (C) CRS was limited to grade 1 and 2 events with more frequent dosing within the first week. For multiple CRS events for a patient at a dosing visit, the record with maximum CRS grade was used in the analysis. The denominator for percentages is the number of patients (n) dosed at each visit. C, cycle; D, day.