Genome-wide MAF binding and shaping of chromatin activity by ectopic MAF. (A) Heatmap of MAF chromatin binding as assessed using ChIP-seq in U266 cells transduced with EV or vector encoding MAF complementary DNA (OE). (B) Motif enrichment at MAF-bound genomic areas. (C) MA plots showing genome-wide enrichment for the indicated histone marks. (D) Heatmaps showing MAF-bound chromatin areas with preexisting (shared) or de novo enrichment (MAF-specific) for the indicated histone marks. OE, overexpression.