Prognostic factor analysis for long-term PFS and OS for the FCR300 cohort. (A) PFS and OS for the overall cohort. (B) PFS according to IGHV-MS. (C) OS according to IGHV-MS. The purple line represents expected survival of a US reference population matched for age, sex, and year. (D) PFS according to IGHV and MRD status at the end of therapy. Neg, undetectable MRD; pos, MRD-positive.