Landscape and prognostic significance of additional genetic alterations in adult KMT2A-r BCP-ALL. (A) Heatmap of recurrent gene alterations, including mutations and deletions, detected by targeted sequencing. (B-C) Forest plots showing the HRs of CIR (B) and OS (C), estimated by univariable Cox proportional-hazards model, for genes found altered in >5% of cases. (D-E) CIR (D) and OS (E) rates in patients according to TP53 and IKZF1 alteration status.