Characterization of IC1 aGVHD noncanonical immune niche. (A) The immune deconvolution heat map, showing distribution of different cellular phenotypes across clusters. (B) Volcano plot of differential enrichment of immune cell types. (C) Hub gene analysis of the top 10 most interacting genes/proteins enriched in IC1, identified by CytoHubba application on Cytoscape software. Red to yellow coloring correlated with decreasing interaction stores. (D) Gene Ontology pathways enriched in IC1, demonstrating multiple gene sets associated with DNA damage and cell cycle.