Figure 3.
DuDS mice have more activated CD8 T cells with a distinct immunological profile. (A) Total number of splenic CD8 and CD4 T cells. (B) Percentage of CD8 T cells homeostatically expressing activation markers IL-18r1 and PD-1 in various organs. Graph shows combined data from >3 experiments; each data point represents a mouse. P value based on one-way ANOVA with Tukey post hoc test of comparisons between Il18tg to DSKO. ∗∗∗∗P < .0001; ∗∗P < .001; ∗P < .05. (C) Unbiased K means clustering t-distributed stochastic neighbor embedding projection of splenic T cells (7649 cells per mouse) from 3 mice of each genotype with representation of each cluster within each genotype. (D) Heat map of relative geometric mean fluorescent intensity (MFI) of selected markers. ILN, inguinal lmph node; MLN, mesenteric lymph node; WT, wild-type.

DuDS mice have more activated CD8 T cells with a distinct immunological profile. (A) Total number of splenic CD8 and CD4 T cells. (B) Percentage of CD8 T cells homeostatically expressing activation markers IL-18r1 and PD-1 in various organs. Graph shows combined data from >3 experiments; each data point represents a mouse. P value based on one-way ANOVA with Tukey post hoc test of comparisons between Il18tg to DSKO. ∗∗∗∗P < .0001; ∗∗P < .001; ∗P < .05. (C) Unbiased K means clustering t-distributed stochastic neighbor embedding projection of splenic T cells (7649 cells per mouse) from 3 mice of each genotype with representation of each cluster within each genotype. (D) Heat map of relative geometric mean fluorescent intensity (MFI) of selected markers. ILN, inguinal lmph node; MLN, mesenteric lymph node; WT, wild-type.

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