DS^KO CD8 T cells have a unique, terminally differentiated transcriptional profile with effector and exhaustion features. (A) Principal component analysis (PCA) from bulk CD8 T-cell RNA sequencing of >3 adult mice from each genotype under homeostatic conditions. (B) Heat map comparison of selected genes of homeostatic CD8 T cells and terminal T_EXs from tumor and chronic infection (LCMV-Cl13).⁶² Crosses within data point (A) and black bars under genotype (B) indicate CD44^LoCD62L^⁻ CD8 T cells, otherwise CD44⁺ CD8 T cells. Rows are z-score normalized.