Natural history of albuminuria in pediatrics and murine model of SCA. (A) Variability in ACR after first episode of albuminuria ≥100 mg/g in pediatrics SCA, 1-year observed mean change in ACR was a decrease of 95.4 mg/g (baseline to year 1, 215.1-119.7 mg/g) with a SD of (132.7 mg/g); (B) variability in urinary albumin excretion in murine SCA model before hyperfiltration phase presents with downward trend over a time of 4 weeks (n = 21); (C) variability in urinary albumin excretion in murine SCA model after hyperfiltration phase presents with upward trend over a time of 4 weeks (n = 18).