Survival curves in patients of the control and vitamin C/D groups. (A) EFS. Control group: 1-year EFS, 59% (95% CI, 53-65); 3-year EFS, 36% (95% CI, 30-42); 5-year EFS, 32% (95% CI, 26-38). Vit C/D group: 1-year EFS, 57% (95% CI, 53-62); 3-year EFS, 34% (95% CI, 29-38); 5-year EFS, not estimated. (B) RFS. Control group: 1-year RFS, 64% (95% CI, 57-70); 3-year RFS, 41% (95% CI, 35-48); 5-year RFS, 37% (95% CI, 31-44). Vitamin C/D group: 1-year RFS, 58% (95% CI, 50-66); 3-year RFS, 37% (95% CI, 27-46); 5-year RFS, not estimated. (C) CIR. Control group: 1-year CIR, 34% (95% CI, 29-39); 3-year CIR, 52% (95% CI, 47-57); 5-year CIR, 54% (95% CI, 48-60). Vitamin C/D group: 1-year CIR, 34% (95% CI, 29-39); 3-year CIR, 50% (95% CI, 45-56); 5-year CIR, not estimated. (D) OS. Control group: 1-year OS, 72% (95% CI, 66-77); 3-year OS, 49% (95% CI, 43-55); 5-year OS, 39% (95% CI, 33-46). Vitamin C/D group: 1-year OS, 73% (95% CI, 66-79); 3-year OS, 47% (95% CI, 38-56); 5-year OS, not estimated.