Thrombin generation in children with SCD treated with hydroxycarbamide compared to blood transfusion. Comparisons between the HC and BT cohorts are shown including (A) thrombin generation curves from representative individuals within each cohort; (B) the quantitative parameters of endogenous thrombin potential, (C) peak thrombin, and (D) velocity index. Comparisons between groups were assessed by the Mann-Whitney U test. (E) Correlation between plasma FVIII:C levels and peak thrombin generated. Correlations were evaluated using the Spearman rank correlation test; ∗P < .05, ∗∗P < .01, ∗∗∗P < .001, and ∗∗∗∗P < .0001.