Algorithm proposed for the diagnosis of aCML. FISH, fluorescence in situ hybridization; MDS/MPN-RS-T, myelodysplastic/ myeloproliferative neoplasms with ring sideroblasts and thrombocytosis; M/L-Eo, myeloid/lymphoid neoplasms with eosinophilia; NGS, next-generation sequencing; PCR, polymerase chain reaction.