Mutation frequency of MDS- and AML-related genes sorted by descending frequency in patients with DDX41-WT. Mutation frequencies in patients with DDX41-WT MDS are illustrated in red and in patients with MDS with germ line LP/P DDX41 variant in blue (A). Mutation frequencies in patients with DDX41-WT AML are illustrated in red and in patients with AML with germ line LP/P DDX41 variant in blue (B). ∗P < .001 (Fisher exact test).