Figure 2.
Pathological evaluation of a patient with PIK3CAM1043V-mutated Langerhans cell histiocytosis. (A) Lung wedge biopsy showing infiltration of lung parenchyma by Langerhans cell histiocytosis (red oval) (H&E; 100× magnification). (B) CD1a immunohistochemistry confirming infiltration of lung parenchyma by Langerhans cell histiocytosis (red oval) (CD1a immunohistochemistry; 100× magnification). (C) Phospho-ERK1/2 (pERK1/2) immunohistochemistry demonstrating a lack of expression of pERK1/2 by the Langerhans cell histiocytosis of the patient (pERK1/2 immunohistochemistry; 100× magnification). (D) PIK3CA c.3127A>G; p.M1043V missense mutation detected by targeted next-generation sequencing of the Langerhans cell histiocytosis involving the lung biopsy of the patient that was absent in paired normal fingernail DNA.

Pathological evaluation of a patient with PIK3CAM1043V-mutated Langerhans cell histiocytosis. (A) Lung wedge biopsy showing infiltration of lung parenchyma by Langerhans cell histiocytosis (red oval) (H&E; 100× magnification). (B) CD1a immunohistochemistry confirming infiltration of lung parenchyma by Langerhans cell histiocytosis (red oval) (CD1a immunohistochemistry; 100× magnification). (C) Phospho-ERK1/2 (pERK1/2) immunohistochemistry demonstrating a lack of expression of pERK1/2 by the Langerhans cell histiocytosis of the patient (pERK1/2 immunohistochemistry; 100× magnification). (D) PIK3CA c.3127A>G; p.M1043V missense mutation detected by targeted next-generation sequencing of the Langerhans cell histiocytosis involving the lung biopsy of the patient that was absent in paired normal fingernail DNA.

Close Modal
This Feature Is Available To Subscribers Only

or Create an Account

Close Modal
Close Modal