HCT alleviates disease burden in CGD. Left column: concept (retrospective and prospective part) of the multicenter study on outcomes after allo-HCT in patients with CGD. Right column, upper part: outcomes with 3-year overall/event-free survival (3y-OS/3y-EFS) and factors influencing outcome after HCT. Lower part: disease burden (total inflammatory disease and CGD infections) at baseline and at 1, 2, and 3 to 5 years after HCT in comparison to the group that did not undergo transplant (Non-HCT). CI, cumulative incidence.