Hematologic findings and clinical bleeding severity. Comparison of laboratory values between patients and controls for platelet counts (A), mean platelet volume (B), immature platelet fraction based on the sex (C), hemoglobin (D), absolute eosinophil count (F), and ARC (G). The hemoglobin and ARC comparisons are further separated into sex categories (E) and (H), respectively, showing a statistically significant difference between the 2 male groups for hemoglobin. Patient ARC plotted vs hemoglobin values (I). ISTH-BAT scores for patients with FPDMM separated according to sex (J). Scores are further divided by the patient’s type of RUNX1 variant for adult women (K), and for adult male and children combined (L). Children are ages ≤14 years, men and women are ages ≥17 years. Dotted green lines indicate abnormal cutoff for sex/age. In panel L, the cutoff for adult males is used, which is higher than the cutoff for children. Bars in panels A-H indicate mean and 1 standard deviation. Hgb, hemoglobin.