Study flowchart for the reported fixed-dose extension period analysis. The study flowchart of this nonrandomized phase 2 trial is adapted from the format of the Consolidated Standards of Reporting Trials (CONSORT) flow diagram for randomized trials. Examples why patients did or could not participate included personal reasons such as a busy schedule, not willing to participate in experimental studies, or the COVID-19 pandemic and medical reasons such as Hb level >11.1 g/dL at baseline, no adequate organ function (ie, elevated transaminase levels), or a wish for children. n, number of patients.