Distribution of refined COO in Japanese patients with DLBCL. (A) Gene expression profiling–based molecular classification algorithm using the DLBCL90 assay. (B) The number of patients with COO classification (inner circle) and with DZsig classification separated into a new class (outer circle). For the latter, the overall distribution between classes is shown in the bar graph. (C) Heat map shows the Lymph2Cx component of the DLBCL90 assay with the 15 informative genes shown as rows, and all 1050 DLBCLs shown as columns. Arrayed below the heat map are clinical characteristics of the tumors. (D) Comparison of the distribution of molecular subtypes according to age group. Multinomial logistic regression P value (GCB vs ABC) is shown above the bar plot. (E) The number of patients in the BCC cohort, with COO classification (inner circle) and DZsig classification (outer circle) separated into new classes. (F) Bar plot showing the distribution of refined COO in the 2 cohorts compared using Fisher exact test. Ind, indeterminate; mRNA, messenger RNA; Neg, negative; OHSG, Okayama Hematology Study Group; Pos, positive.