Prognostic significance of molecular classification of DLBCL. (A,B) Kaplan-Meier curves represent PFS and OS, per the molecular subtypes. (C,D) Kaplan-Meier curves showing OS according to the molecular subtypes combined with 2 IPI risk groups: low/low-intermediate–risk IPI group (low) and high/high-intermediate–risk IPI group (high). (E,F) Forest plots show the results of multivariable analyses (PFS and OS). IPI scores were classified into 2 groups as described earlier. DPE, dual protein expressor; ns, not significant; PR, primary refractory. ∗P < .05; ∗∗P < .01; ∗∗∗P < .001; ∗∗∗∗P < .0001.