Phenotypic characterization of the DZsig. (A) Heat map represents the 30 informative DZsig genes shown as rows, and the 432 patients with GCB or DZsig^pos-DLBCLs shown as columns. Arrayed below the heat map are immunohistochemical characteristics of the tumors. (B) Bar plots show the proportion of MYC/BCL2 DPEs, per molecular subtypes. (C) Box plots showing H-score (left) of c-MYC and BCL2, and messenger RNA expression (right) of MYC and BCL2 in DZsig^pos tumors vs GCB tumors, compared using Wilcoxon rank-sum test. (D) Comparison of mean z scores of IHC-positive rate for each antibody per molecular subtypes. mRNA, messenger RNA.